Today I am going to have a look look at the following paper: 

Liu, M., Zhang, Y., Ye, Z., Yang, S., Zhou, C., He, P., Zhang, Y., Hou, F.F. and Qin, X. (2023). Inflammatory Bowel Disease With Chronic Kidney Disease and Acute Kidney Injury. American Journal of Preventive Medicine, [online] 65(6), pp.1103–1112. doi:https://doi.org/10.1016/j.amepre.2023.08.008.

With my ongoing gut and according to my bloodwork kidney issues this paper came up in my research. As always please not I am no longer a scientific researcher and am outside of my area of expertise, this is just what I can tell from a look at the paper and knowledge I have left from 12 years ago when I was in science, I am not a medical doctor and this is not medical advice.  

Summary:

• Study analysed data from UK Biobank to assess the risk of chronic kidney disease (CKD) and acute kidney injury (AKI) in individuals with inflammatory bowel disease (IBD).

• Participants with IBD had a significantly higher risk of CKD and AKI compared to those without IBD.

• The study highlights the importance of monitoring kidney function in patients with IBD.

This study provides valuable insights into the association between IBD and kidney diseases, emphasizing the need for proactive monitoring in clinical practice.

Detailed Summary:

- Individuals with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are at a higher risk of developing chronic kidney disease (CKD) and acute kidney injury (AKI).

- Potential mechanisms contributing to the increased risk include electrolyte abnormalities due to intestinal inflammation, dysbiosis leading to uremic toxins, and immune system alterations promoting renal disease progression.

- The association between IBD and kidney issues is independent of genetic risks of kidney diseases, and the risk is higher in younger participants compared to older individuals, highlighting the importance of monitoring kidney function in patients with IBD.

Antibiotics can lead to IBD?

I am hoping to start doing some short posts (and maybe some longer ones) looking at various aspects of science. I do aim to look at running and carnivore papers (not that such a thing would ever get any funding) but at the moment I am researching a lot into my gut issues and potential causes. 

The reason that this article actually caught my attention is because I generally have to stop taking antibiotics due to the severe stomach cramps and diarrhoea that it causes, I might in fact cover a paper next that shows antibiotic use can trigger flare ups. Anyway.

Not say I have IBD, though as discussed before many of the symptoms line up (for a mild case at least) and during that I came across a podcast about a research paper on antibiotic use and its potential link to IBD. 

Faye, A.S., Allin, K.H., Iversen, A.T., Agrawal, M., Faith, J., Colombel, J.-F. and Jess, T. (2023). Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study. Gut, [online] 72(4), pp.663–670. doi:https://doi.org/10.1136/gutjnl-2022-327845.

The basic conclusion of this study is that "Antibiotic exposure is associated with an increased risk of IBD, and was highest among individuals aged 40 years and older. This risk increased with cumulative antibiotic exposure.."

So there you go, there is a chance that taking antibiotics increases your risk of developing IBD. Of course you should take any medication you are advised to take and this information is me sharing the research and should not be considered medical advice. 

ibd, medical, paper, antibiotics, Crohn's, runner, gut, diarrhoea, stomach cramps,