Today I am going to have a look look at the following paper: 

Liu, M., Zhang, Y., Ye, Z., Yang, S., Zhou, C., He, P., Zhang, Y., Hou, F.F. and Qin, X. (2023). Inflammatory Bowel Disease With Chronic Kidney Disease and Acute Kidney Injury. American Journal of Preventive Medicine, [online] 65(6), pp.1103–1112. doi:https://doi.org/10.1016/j.amepre.2023.08.008.

With my ongoing gut and according to my bloodwork kidney issues this paper came up in my research. As always please not I am no longer a scientific researcher and am outside of my area of expertise, this is just what I can tell from a look at the paper and knowledge I have left from 12 years ago when I was in science, I am not a medical doctor and this is not medical advice.  

Summary:

• Study analysed data from UK Biobank to assess the risk of chronic kidney disease (CKD) and acute kidney injury (AKI) in individuals with inflammatory bowel disease (IBD).

• Participants with IBD had a significantly higher risk of CKD and AKI compared to those without IBD.

• The study highlights the importance of monitoring kidney function in patients with IBD.

This study provides valuable insights into the association between IBD and kidney diseases, emphasizing the need for proactive monitoring in clinical practice.

Detailed Summary:

- Individuals with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are at a higher risk of developing chronic kidney disease (CKD) and acute kidney injury (AKI).

- Potential mechanisms contributing to the increased risk include electrolyte abnormalities due to intestinal inflammation, dysbiosis leading to uremic toxins, and immune system alterations promoting renal disease progression.

- The association between IBD and kidney issues is independent of genetic risks of kidney diseases, and the risk is higher in younger participants compared to older individuals, highlighting the importance of monitoring kidney function in patients with IBD.

Creatinine gone back up

Frustratingly my blood test came back at 6pm on a Friday, because of course it did. And it also showed that my creatinine has gone back up to where it was when I was unwell with the infection. This might help me get some more tests at least but does suggest that my kidney function could be impaired.  

I am not a doctor so I will try and not spend the weekend guessing everything that could be going on. I personally still think it could be linked to the underlying gut issue, not through dehydration as I am drinking well and not going that often but because papers that I will try and summarise (in another post) suggest that IBD / gut issues can link to kidney damage. Though the decline since Feb suggests it is something acute that has caused the decreased kidney function. It is also the decline, well increase in number but decrease in function, that suggests it is nothing to do with the carnivore diet. I say this because a high meat diet is known to increase creatinine levels. 

Will update once I have spoken to the doctors. Hopefully my Op in June can still go ahead and hopefully we can get my a settled tummy and back to 100%.